期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 85, 期 1, 页码 69-76出版社
OXFORD UNIV PRESS
DOI: 10.1093/bbb/zbaa051
关键词
peptaibols; cytotoxicity; K562; fungi; natural product
类别
资金
- JSPS KAKENHI [JP17H06412, JP20K05858]
A new peptaibol, RK-026A, was isolated from a fungus Trichoderma sp. RK10-F026, along with other cytotoxic compounds. The structure of RK-026A was determined as a new derivative containing Glu at the 18th residue. RK-026A exhibited cytotoxicity against K562 leukemia cells.
A new peptaibol, RK-026A (1) was isolated from a fungus, Trichoderma sp. RK10-F026, along with atroviridin B (2), alamethicin II (3), and polysporin B (4) as a cytotoxic compound, which was selected by principal component analysis of the MS data from 5 different culture conditions. The structure of 1 was determined as a new atroviridin B derivative containing Glu at the 18th residue instead of Gln by NMR and HR-MS analyses including the investigation of detailed MS/MS fragmentations. 1 showed cytotoxicity toward K562 leukemia cells at an IC50 value of 4.1 mu m.
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