4.7 Article

A cysteine-selective fluorescent probe for monitoring stress response cysteine fluctuations

期刊

CHEMICAL COMMUNICATIONS
卷 57, 期 47, 页码 5810-5813

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc01110c

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资金

  1. Natural Science Foundation of China [21778026, 21701074, 21402077, 21976209]
  2. Program of Youth Innovation Promotion Association, CAS [2019217]
  3. Taishan Scholar Project Special Funding [TS20190962]

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Rare studies have provided evidence for real-time monitoring of stress response cysteine fluctuations. A cysteine-selective fluorescent probe was successfully designed and synthesized to monitor these fluctuations, providing visual evidence of Hg2+ regulated cysteine fluctuations for the first time, which may help researchers uncover the mechanism of heavy metal ion poisoning.
Rare studies provided evidence for the real-time monitoring of stress response cysteine fluctuations. Here, we have successfully designed and synthesized a cysteine-selective fluorescent probe 1 to monitor stress response Cys fluctuations, providing visual evidence of Hg2+ regulated cysteine fluctuations for the first time, which may open a new way to help researchers to reveal the mechanism of heavy metal ion poisoning.

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