期刊
BIOMATERIALS SCIENCE
卷 9, 期 14, 页码 4843-4853出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1bm00128k
关键词
-
资金
- National Natural Science Foundation of China [51873176, 21967001]
- Hong Kong Research Grants Council [PolyU153058/19P]
- Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional Materials [2019B121205002]
- Hong Kong Polytechnic University [1-ZE1C]
- Double-Thousand Talents Plan of Jiangxi Province
- Ms Clarea Au for the Endowed Professorship in Energy [847S]
Iridium(iii) complexes, such as NIR-Ir-XE, conjugated with xanthene dye show promising properties for mitochondria-targeted imaging and cancer phototherapy. The generation of singlet oxygen after irradiation with visible light makes them effective in photodynamic therapy. Comparisons with xanthene-free counterparts demonstrate higher singlet oxygen generation efficiency and better therapeutic effects.
Iridium(iii) complexes are potent candidates for photodynamic therapy (PDT), but some key drawbacks still hamper clinical translation, such as poor operability in the phototherapeutic window, high dark toxicity, and low reactive oxygen species (ROS) production efficiency. In this work, a near-infrared phosphorescent Ir(iii) complex conjugated to a xanthene dye, NIR-Ir-XE, is reported with highly favourable properties for mitochondria-targeted imaging and cancer phototherapy. The generation of the triplet excited state of a xanthene moiety endows the NIR-Ir-XE to form singlet oxygen (O-1(2)) for use as a photodynamic therapy agent after irradiation with visible light. Compared with the xanthene-free Ir(iii) counterpart (NIR-Ir-bpy), the xanthene-modified cyclometalated Ir(iii) photosensitizer NIR-Ir-XE exhibits higher O-1(2) generation efficiency, negligible dark toxicity and a better therapeutic effect. Importantly, a clear correlation between cell death and intracellular generation of O-1(2) derived from NIR-Ir-XE after light irradiation was demonstrated. The corresponding in vivo photo-antitumor performance was further demonstrated to be effective in tumor-bearing mice. The observed properties of NIR-Ir-XE qualify it as a promising PDT agent.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据