期刊
AMERICAN JOURNAL OF CHINESE MEDICINE
卷 49, 期 4, 页码 805-828出版社
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S0192415X21500385
关键词
Colorectal Cancer; Gut Microbiota; Traditional Chinese Medicine
资金
- National Natural Science Foundation of China [81573813, 81173598]
- Excellent Talent Program of Chengdu University of Traditional Chinese Medicine [YXRC2019002, ZRYY1917]
- Fund of Scientific Research Innovation Team Construction in Sichuan Provincial University [18TD0017]
The text discusses the pathogenesis of colorectal cancer, the types and functions of gut microbiota, and the research on traditional Chinese medicine in treating colorectal cancer by regulating the gut microbiota. It emphasizes the importance of regulating the gut microbiota for disease treatment.
Based on the study and research on the pathogenesis of colorectal cancer, the types and functions of gut microbiota, and its role in guiding and regulating the occurrence and development of diseases, we have explored the mechanism of traditional Chinese medicine in the treatment of colorectal cancer by regulating the gut microbiota. Genetic variation, abnormal responses of innate and adaptive immunity, mucosal barrier dysfunction, imbalance of intestinal microbial colonization, personal and environmental risk factors are the main pathogenesis of colorectal cancer. The gut microbiota mainly includes Sclerotium (including Clostridium, Enterococcus, Lactobacillus and Ruminococcus) and Bacteroides (including Bacteroides and Prevotella), which have biological antagonism, nutrition for the organism, metabolic abilities, immune stimulation, and ability to shape cancer genes functions to body. The gut microbiota can be related to the health of the host. Current studies have shown that Chinese herbal compound, single medicinal materials, and monomer components can treat colorectal cancer by regulating the gut microbiota, such as Xiaoyaosan can increase the abundance of Bacteroides, Lactobacillus, and Proteus and decrease the abundance of Desulfovibrio and Rickerella. Therefore, studying the regulation and mechanism of gut microbiota on colorectal cancer is of great benefit to disease treatment.
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