Ultrasensitive and ratiometric two-photon fluorescence imaging of Golgi polarity during drug-induced acute kidney injury

We synthesized an ultrasensitive probe TP-Golgi for the two-photon ratiometric fluorescence imaging of Golgi polarity. Probe TP-Golgi possesses a large Stokes shift, excellent sensitivity and good selectivity to quantitatively detect environmental polarity. By application of TP-Golgi, we found that the Golgi polarity increased obviously in the kidneys of mice with AKI.

Automated summary

The research team synthesized a highly sensitive probe named TP-Golgi, which can quantitatively detect environmental polarity. Application of TP-Golgi in the kidneys of mice with AKI revealed a significant increase in Golgi polarity.