期刊
NATURAL PRODUCT REPORTS
卷 38, 期 4, 页码 843-860出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0np00054j
关键词
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资金
- NSFC [21977071]
- STCSM [18401933500]
- Opening Fund of State Key Lab of Bio-organic and Natural Products Chemistry
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
- FAMRI
- SEMC [2019-01-07-00-10-E00072]
This review summarizes the progress in material sourcing, molecular mechanisms, clinical progress, and new drug design strategies of triptolide over the past two decades, and discusses some prospects for the future development of triptolide.
Covering: 2000 to 2020 Triptolide is a bioactive diterpene triepoxide isolated from Tripterygium wilfordii Hook F, a traditional Chinese medicinal plant whose extracts have been used as anti-inflammatory and immunosuppressive remedies for centuries. Although triptolide and its analogs exhibit potent bioactivities against various cancers, and inflammatory and autoimmune diseases, none of them has been approved to be used in the clinic. This review highlights advances in material sourcing, molecular mechanisms, clinical progress and new drug design strategies for triptolide over the past two decades, along with some prospects for the future course of development of triptolide.
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