Autoxidation vs. antioxidants - the fight for forever

Autoxidation limits the longevity of essentially all hydrocarbons and materials made therefrom - including us. The radical chain reaction responsible often leads to complex mixtures of hydroperoxides, alkyl peroxides, alcohols, carbonyls and carboxylic acids, which change the physical properties of the material - be it a lubricating oil or biological membrane. Autoxidation is inhibited by addtitives such as radical-trapping antioxidants, which intervene directly in the chain reaction. Herein we review the most salient features of autoxidation and its inhibition, emphasizing concepts and mechanistic considerations important in understanding this chemistry across the wide range of contexts in which it is relevant.

Automated summary

Autoxidation limits the longevity of hydrocarbons and materials by leading to complex mixtures of compounds that alter their physical properties. Antioxidants can inhibit this process by intervening directly in the chain reaction. Understanding the mechanistic considerations of autoxidation is important across various contexts.