期刊
ADVANCED BIOLOGY
卷 5, 期 6, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adbi.202000624
关键词
host– pathogens; immunology; in vitro models; infection; lungs; pathogens; respiratory system
资金
- Engineering and Physical Sciences Research Council Centre for Doctoral Training in Sensor Technologies and Applications [EP/L015889/1]
- European Union's Horizon 2020 Research and Innovation Programme under the Marie Skodowska-Curie Grant [842356]
- Marie Curie Actions (MSCA) [842356] Funding Source: Marie Curie Actions (MSCA)
Respiratory diseases and lower respiratory tract infections are major causes of death globally, especially with the recent impact of the COVID-19 pandemic. In vitro models that accurately represent lung microenvironments are becoming increasingly important for studying biological and immunological components related to respiratory health and diseases, as well as for addressing ethical concerns and improving research efficiency.
Respiratory diseases and lower respiratory tract infections are among the leading cause of death worldwide and, especially given the recent severe acute respiratory syndrome coronavirus-2 pandemic, are of high and prevalent socio-economic importance. In vitro models, which accurately represent the lung microenvironment, are of increasing significance given the ethical concerns around animal work and the lack of translation to human disease, as well as the lengthy time to market and the attrition rates associated with clinical trials. This review gives an overview of the biological and immunological components involved in regulating the respiratory epithelium system in health, disease, and infection. The evolution from 2D to 3D cell biology and to more advanced technological integrated models for studying respiratory host-pathogen interactions are reviewed and provide a reference point for understanding the in vitro modeling requirements. Finally, the current limitations and future perspectives for advancing this field are presented.
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