期刊
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
卷 5, 期 3, 页码 412-419出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TRPMS.2020.3009913
关键词
Wounds; Plasmas; Skin; Indexes; Hyperspectral imaging; Biomedical imaging; Mice; Full-thickness skin wounds; mouse model; plasma medicine; reactive oxygen and nitrogen species; skin microcirculation
资金
- Ministry of Education, Science, and Culture of the State of Mecklenburg-Western Pomerania, Germany
- European Union, European Social Fund [AU 11 038, ESF/IV-BM-B35-0010/13, AU 15 001]
- German Federal Ministry of Education and Research [03Z22DN11, 03Z22Di1]
The study investigated the effects of plasma treatment on wound tissue oxygenation and perfusion, revealing that plasma treatment can promote tissue oxygenation and induce changes in tissue hemoglobin and tissue water index during reactive species-driven wound healing.
Efficient vascularization of skin tissue supports wound healing in response to injury. This includes elevated blood circulation, tissue oxygenation, and perfusion. Cold physical plasma promotes wound healing in animal models and humans. Physical plasmas are multicomponent systems that generate several physicochemical effectors, such as ions, electrons, reactive oxygen and nitrogen species, and UV radiation. However, the consequences of plasma treatment on wound oxygenation and perfusion, vital processes to promote tissue regeneration, are largely unexplored. We used a novel hyperspectral imaging (HSI) system and a murine dermal full-thickness wound model in combination with kINPen argon plasma jet treatment to address this question. Plasma treatment promoted tissue oxygenation in superficial as well as deep (6 mm) layers of wound tissue. In addition to perfusion changes, we found a wound healing stage-dependent shift of tissue hemoglobin and tissue water index during reactive species-driven wound healing. Contactless, fast monitoring of medical parameters in real-time using HSI revealed a plasma-supporting effect in wound healing together with precise information about biological surface-specific features.
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