期刊
FERTILITY AND STERILITY
卷 107, 期 4, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2017.01.021
关键词
Assisted reproduction technology; egg donation program; perinatal outcomes; vitrification
资金
- SGR project (Suport de Grups de Recerca)
Objective: To ascertain whether perinatal outcomes are affected by vitrification and/or controlled ovarian hyperstimulation (COH). Design: Register-based cohort study. Setting: Not applicable. Patient(s): Women undergoing in vitro fertilization (IVF) between 2008 and 2012 using autologous or donated eggs who had a singleton pregnancy delivered from the 24th week onward. Intervention(s): Fresh embryo transfer (ET) or frozen-thawed ET in women undergoing IVF. Main Outcome Measure(s): Primary outcome birthweight, and secondary outcomes gestational age at delivery, small for gestational age, mode of delivery, and perinatal mortality. Result(s): In the autologous egg population, newborns from the fresh ET group had lower birthweight than the frozen-thawed ET group (3,152.9 +/- 545.5g and 3,343.2 +/- 532.3g, respectively), and this difference persisted even after adjusting for confounding factors, and the newborns had a higher risk of being small for gestational age (SGA). In contrast, among egg-donor recipients undergoing ET, the mean birthweight did not differ between the groups (3,165 +/- 604.15 g and 3,143.60 +/- 604.21g in the fresh and frozen-thawed ET groups, respectively); however, in the adjusted regression model birthweight was statistically significantly higher in the fresh ET group than the frozen-thawed ET group. The risk of SGA remained comparable between the fresh versus frozen-thawed ET groups. We observed no statistically significant differences in perinatal mortality between groups either in the autologous egg population or in the donor recipient group. Conclusion(s): Perinatal outcomes are negatively affected by COH and not affected by the vitrification process. (C) 2017 by American Society for Reproductive Medicine.
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