期刊
FERTILITY AND STERILITY
卷 108, 期 4, 页码 558-567出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2017.08.022
关键词
Conventional stimulation; in vitro fertilization; mild stimulation; minimal stimulation
资金
- Actavis/Watson/Uteron
- Controversies in Obstetrics Gynecology
- Dutch Heart Foundation
- Dutch Medical Research Council
- Euroscreen/Ogeda
- Ferring
- London Womens Clinic
- Merck Serono
- Netherland Genomic Initiative
- OvaScience
- Pantharei Bioscience
- PregLem/Gedeon Richter/Finox
- Reproductive Biomedicine Online
- Roche
- Teva
- World Health Organization
It has been proven that the use of high gonadotropin dose does not necessarily improve the final outcome of IVF. Mild ovarian stimulation is based on the principle of optimal utilization of competent oocytes/embryos and endometrial receptivity. There is growing evidence that the pregnancy or live birth rates with mild-stimulation protocols are comparable to those with conventional IVF; the cumulative pregnancy outcome has been shown to be no different, despite having fewer numbers of oocytes or embryos available with milder ovarian stimulation. Although equally effective, mild-stimulation IVF is associated with a greater safety profile, in terms of the incidence of ovarian hyperstimulation syndrome and venous thromboembolism. It is also found to be better tolerated by patients and less expensive. Emerging research evidence may lead to widespread acceptance of mild IVF, by both patients and IVF providers, and make IVF more accessible to women and couples worldwide. (C) 2017 by American Society for Reproductive Medicine.
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