Nanostructure, porosity and tensile strength of PVA/Hydroxyapatite composite nanofiber for bone tissue engineering

Hydroxyapatite [HAp, Ca10(PO4)6(OH)2] was successfully synthesized using natural minerals, precisely limestone from Druju Indonesia. As a bone scaffold compound, HAp has a weakness of low mechanical properties therefore it needs to be mixed with polymeric materials, such as polyvinyl alcohol (PVA) to improve its mechanical properties. The PVA/HAp composites nanofiber have successfully synthesized using the electrospinning method and analyzed including nanostructure, porosity and tensile strength of nanofiber. The diameter of PVA/HAp composites nanofiber in 173 to 234 nm, porosity in 62 to 74%, and tensile strength in 6.96 to 15.85 MPa. Increasing of HAp cocentrasion increase of tensile strength, SEM showed an increase in HAp concentration (0%-20%) causing a decrease in the average diameter of the fiber. The characteristics of PVA/HAp composite nanofiber can be applied as a scaffold in bone tissue engineering. ? 2020 Elsevier Ltd. All rights reserved. Selection and peer-review under responsibility of the scientific committee of the 7th International Conference of Advanced Materials Science and Technology 2019.

Automated summary

Hydroxyapatite was successfully synthesized from natural minerals in Indonesia and composite nanofibers were prepared by mixing it with polymeric materials, showing potential applications in bone tissue engineering.