期刊
GREEN CHEMICAL ENGINEERING
卷 2, 期 2, 页码 197-206出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.gce.2020.09.007
关键词
Artemisinin; Cyclodextrin derivative; Aqueous solution; Ultrasonic assisted extraction; Complex
资金
- Innovation Academy for Green Manufacture, Chinese Academy of Sciences [IAGM-2019- A12]
- National Natural Science Foundation of China [22078324]
- CAS Pioneer Hundred Talents Program
- K. C. Wong Education Foundation [GJTD-2018-04]
The study proposed a method for extracting artemisinin from Artemisia annua L. using an aqueous solution of cyclodextrin derivative under ultrasonic irradiation, with the system containing edible hydroxypropyl-beta-cyclodextrin (HPBCD) proving to be efficient. Optimal extraction conditions were predicted using artificial neural network, resulting in significantly higher extraction amount of Ars compared to water. The study also showed that HPBCD enhanced the equilibrium amount of Ars in water, while ultrasonic irradiation accelerated extraction rate and reduced activation energy.
A process for extraction of artemisinin (Ars) from Artemisia annua L. based on aqueous solution of cyclodextrin derivative under ultrasonic irradiation was proposed. Among the test additives, the system containing edible hydroxypropyl-beta-cyclodextrin (HPBCD) was shown to be efficient for this extraction. The optimal extraction conditions were predicted by artificial neural network, under which the extraction amount of Ars could reach 8.66 mg per gram of the leaves, much higher than the value in water (1.70 mg g-1). Kinetics study indicated that HPBCD enhanced the equilibrium amount of Ars in water, and ultrasonic irradiation accelerated extraction rate and reduced the activation energy. Mechanism study showed that the formation of Ars-HPBCD complex during extraction enhanced the water solubility of Ars and facilitated the extraction, and the configuration of Ars-HPBCD complex was modeled by molecular docking, which was further verified by characterizations. This work provides a convenient way to fabricate the traditional tea-based medicament of natural drugs to make production of this famous antimalarial medicine cheaper.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据