4.7 Article

Ultrathin functionalized covalent organic framework nanosheets for tumor-targeted photodynamic therapy

期刊

CHEMICAL COMMUNICATIONS
卷 57, 期 49, 页码 6082-6085

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc02124a

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资金

  1. National Natural Science Foundation of China [21927811, 21874086, 21775094]
  2. National Key R&D Program of China [2019YFA0210100]
  3. Youth Innovation Science and Technology Program of Higher Education Institution of Shandong Province [2019KJC022]

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A modification-facilitated exfoliation strategy was developed for the preparation of ultrathin 2D functionalized covalent organic framework nanosheets (COF NSs) in a single step. The hyaluronic acid-functionalized ultrathin porphyrin COF NSs with enhanced reactive oxygen species (ROS) generation effect were prepared for tumor-targeted photodynamic therapy.
We developed a modification-facilitated exfoliation strategy for the one-step preparation of ultrathin 2D functionalized covalent organic framework nanosheets (COF NSs). Hyaluronic acid-functionalized ultrathin porphyrin COF NSs (about 5-8 nm) with enhanced reactive oxygen species (ROS) generation effect were readily prepared for tumor-targeted photodynamic therapy.

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