期刊
CHEMICAL SCIENCE
卷 12, 期 24, 页码 8531-8536出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1sc01731d
关键词
-
资金
- National Natural Science Foundation of China [21971196]
The study presents a Pd-catalyzed cascade reaction for the cross-electrophile coupling and C-H alkylation of 2-iodo-alkoxylarenes with alkyl chlorides, providing access to alkylated phenol derivatives. Methoxy and benzyloxy groups play crucial roles in the reaction by enabling C(sp(3))-H activation.
Transition-metal-catalyzed cross-electrophile C(sp(2))-(sp(3)) coupling and C-H alkylation reactions represent two efficient methods for the incorporation of an alkyl group into aromatic rings. Herein, we report a Pd-catalyzed cascade cross-electrophile coupling and C-H alkylation reaction of 2-iodo-alkoxylarenes with alkyl chlorides. Methoxy and benzyloxy groups, which are ubiquitous functional groups and common protecting groups, were utilized as crucial mediators via primary or secondary C(sp(3))-H activation. The reaction provides an innovative and convenient access for the synthesis of alkylated phenol derivatives, which are widely found in bioactive compounds and organic functional materials.
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