4.6 Article

A novel fast-responsive fluorescent probe based on 1,3,5-triazine for endogenous H2S detection with large Stokes shift and its application in cell imaging

期刊

NEW JOURNAL OF CHEMISTRY
卷 45, 期 22, 页码 9756-9760

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1nj01319j

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资金

  1. Natural Science Foundation of China [21801145]
  2. Shandong Provincial Key R&D Program/Major Science and Technology Innovation Project of Shandong Province [2019JZZY020230]
  3. Natural Science Foundation of Shandong Province [ZR2017BB012]
  4. Program for Science and Technology Innovation Talents in Universities of Henan Province [20HASTIT037]

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The novel fast-responsive fluorescent probe TzAr-H2S can quickly detect H2S with good selectivity, large Stokes shift, and low cytotoxicity within 20 seconds, providing a powerful tool for understanding the regulation mechanism of hydrogen sulfide in cells.
A novel fast-responsive fluorescent probe TzAr-H2S was constructed to realize the imaging of endogenous H2S in living cells. This turn-on fluorescent probe TzAr-H2S can quickly (only 20 s) detect H2S with good selectivity, large Stokes shift (100 nm) and low cytotoxicity, which might provide a powerful tool for understanding the regulation mechanism of hydrogen sulfide in cells.

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