期刊
CELL STRESS
卷 5, 期 5, 页码 55-72出版社
SHARED SCIENCE PUBLISHERS OG
DOI: 10.15698/cst2021.05.248
关键词
obesity; cancer; mouse models; adipokines; metabolism; inflammation; extracellular Matrix remodeling
类别
资金
- Trond Mohn Foundation Starter grant
- Norwegian Research Council [275250]
- Norwegian Cancer Society [207028]
Obesity is epidemiologically linked to 13 forms of cancer, affecting tumors through multiple avenues. Understanding the molecular mechanisms linking obesity and cancer may lead to targeted therapy for obese cancer patients.
Obesity is epidemiologically linked to 13 forms of cancer. The local and systemic obese environment is complex and likely affect tumors through multiple avenues. This includes modulation of cancer cell phenotypes and the composition of the tumor microenvironment. A molecular understanding of how obesity links to cancer holds promise for identifying candidate genes for targeted therapy for obese cancer patient. Herein, we review both the cell-autonomous and non-cell-autonomous mechanisms linking obesity and cancer as well as provide an overview of the mouse model systems applied to study this.
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