4.4 Review

Peptidic Connexin43 Therapeutics in Cardiac Reparative Medicine

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Summary: Compounds that block the function of connexin and pannexin protein channels have shown potential as valuable therapeutics for diseases, but the current literature on their molecular effects on tissues is inconclusive. This review discusses the distinct physiological and pathological implications of blocking different channel types, as well as the contribution of connexins and pannexins to excessive ATP release linked to disease onset and progression.

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