期刊
AGING-US
卷 13, 期 8, 页码 12258-12272出版社
IMPACT JOURNALS LLC
关键词
growth differentiation factor 11; GDF11; aging; transforming growth factor; age-related diseases; regeneration
资金
- National Natural Science Foundation of China [81870593]
- Natural Science Foundation of Shandong Province of China [ZR2018MH008]
- Shandong Province Higher Educational Science and Technology Program for Youth Innovation [2020KJL004]
GDF11 is a critical rejuvenation factor that may improve outcomes in neurodegenerative and neurovascular diseases, as well as muscle health. There is controversy regarding its functional roles, but it shows potential for reversing age-related pathological changes and regulating organ regeneration.
Growth differentiation factor 11 (GDF11), a member of the transforming growth factor beta superfamily of cytokines, is a critical rejuvenation factor in aging cells. GDF11 improves neurodegenerative and neurovascular disease outcomes, increases skeletal muscle volume, and enhances muscle strength. Its wide-ranging biological effects may include the reversal of senescence in clinical applications, as well as the ability to reverse age-related pathological changes and regulate organ regeneration after injury. Nevertheless, recent data have led to controversy regarding the functional roles of GDF11, because the underlying mechanisms were not clearly established in previous studies. In this review, we examine the literature regarding GDF11 in age-related diseases and discuss potential mechanisms underlying the effects of GDF11 in regulation of age-related diseases.
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