期刊
JOURNAL OF ABNORMAL PSYCHOLOGY
卷 130, 期 3, 页码 223-235出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/abn0000618
关键词
depression; neuroticism; stress; reward; ventral striatum
资金
- National Institute of Health [R01-AG045231, R01-AG061162, T32GM008151, R01-HD083614, U01-AG052564, R01-AA027827, R56-AG059265]
- Duke University
- NIDA [DA033369]
- NIH [R01-AG045231, R01-AG061162, R01-HD083614, U01-AG052564, R01-AA027827, R56-AG059265, T32-GM008151]
- NSF [DGE-1143954]
- Klingenstein Third Generation Research Fellowship in Child and Adolescent Depression
- McDonnell Center for Systems Neuroscience at Washington University in St. Louis
Neuroticism may increase vulnerability to stress-related depression and impact the association between stressful life events and reward-related brain responses. Sensitivity to stress-related disruptions in brain processing may underlie vulnerability to clinically significant depression.
Elevated neuroticism may confer vulnerability to the depressogenic effects of stressful life events (SLEs). However, the mechanisms underlying this susceptibility remain poorly understood. Accumulating evidence suggests that stress-related disruptions in neural reward processing might undergird links between stress and depression. Using data from the Saint Louis Personality and Aging Network (SPAN) study and Duke Neurogenetics Study (DNS), we examined whether neuroticism moderates links between stressful life events (SLE) and depression as well as SLEs and ventral striatum (VS) response to reward. In the longitudinal SPAN sample (n = 971 older adults), SLEs prospectively predicted future depressive symptoms, especially among those reporting elevated neuroticism, even after accounting for prior depressive symptoms and previous SLE exposure (NxSLE interaction: p = .016, Delta R-2 = 0.003). Cross-sectional analyses of the DNS, a young adult college sample with neuroimaging data, replicated this interaction (n = 1,343: NxSLE interaction: p = .019, Delta R-2 = 0.003) and provided evidence that neuroticism moderates the association between SLEs and reward-related VS response (n = 1,195, NxSLE: p = .017, Delta R-2 = 0.0048). Blunted left VS response to reward was associated with a lifetime depression diagnosis, r = -0.07, p = .02, but not current depressive symptoms, r = -0.003, p = .93. These data suggest that neuroticism may promote vulnerability to stress-related depression and that sensitivity to stress-related reductions in VS response may be a potential neural mechanism underlying vulnerability to clinically significant depression.
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