Complement Component C3 and C4 in Patients COVID-19 Induced Cytokine Released Storm

Aim: To evolution the complement component C3 and C4 in patients COVID-19 induced cytokine released storm. Methods: The case control study was conducted in Imam AL-Hussain Hospital in Thi-Qar Governorate from February 2020 to September 2020. In our study was forty of them with cytokine storm-induce SARS-COVID 19 depended on clinical feature and lab testing. Hence, fifty persons normally as a control group. The age group between 25 to up to 80 age and both gender included in the current study. Results: The level of IL6 in patients was 107.41 +/- 18.18 Pg/ml, this value showed to be in cytokine storm phenomenon while the control group was 17.41 +/- 5.45 Pg/ml. The differences were highly significant different (P= 0.00). Complement component of C3 and C4 levels of infected patient were (2.47 +/- 0.399) and (0.655 +/- 0.133), respectively showed highly elevated than the normal range. Conclusion: However, ferritin was out of the rang (>2000 ng/mL) and C-reactive protein (CRP) was highly elevated (134.05 +/- 22.67mg/L) showed highly elevated than the normal range. The mean of was ranged interleukin 6 >107.41, ferritin >2000 ng/mL, while, C.R. Protein 134.05mg/L suggested patient with cytokine release storm. However, several anti-cytokine approaches have proven effective in reversing cytokine storm syndromes.

Automated summary

The study found elevated levels of IL6 in COVID-19 patients with cytokine storm, as well as increased levels of complement components C3 and C4. This suggests a correlation between cytokine storm and these immune system factors.