期刊
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
卷 35, 期 2, 页码 571-581出版社
BIOLIFE SAS
关键词
IL-33; IL-25; allergic rhinitis; ovalbumin
资金
- Shanghai Jiao Tong University Med-X Interdisciplinary Research Funding [YG2019QNB25]
Both IL-33 and IL-25 contribute to the pathogenesis of allergic rhinitis, with IL-33 playing a greater role. Neutralization of IL-33 may be a potential therapeutic approach for allergic rhinitis.
Both interleukin (IL)-33 and IL-25 induce Th2-type cytokine production by various cell types, suggesting that they may contribute to development of allergic disorders, however, the immunomodulatory effects of IL-33 and IL-25 in ovalbumin (OVA)-induced allergic rhinitis (AR) remain unclear. In the present study, anti-IL-33 and anti-IL-25 Abs were administrated intranasally during rechallenge in OVA-induced AR. Immunomodulatory effects were evaluated by measuring nasal rubbing, sneezing occurrence, serum OVA-specific antibodies, Th2 immune responses, neutrophil, eosinophil and mast cell recruitment into the nasal mucosa. We found that treatment with anti-IL-33 Ab markedly reduced nasal rubbing, sneezing events, Th2 immune responses, serum OVA-specific IgE and IgG1 levels, mucosal neutrophil, eosinophil and mast cell infiltration. In contrast, the effect of IL-25 antagonism was limited to attenuating the Th2 immune responses, and neutrophil and eosinophil infiltration. These observations indicate that IL-33 and IL-25 play a pathogenic role in an established AR mouse model, with a greater contribution of IL-33 than IL-25. Our findings suggest that IL-33 neutralization may be a potential approach for treatment of AR.
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