Estimating chiral selector potential of micelle-based mobile phases through the analysis of some enantiomeric mixtures

The present work aims to present two new concepts concerned with chiral separation. First, chiral separation of some enantiomeric drugs, using micelle-based liquid chromatography without any chiral selector, whether in the stationary phase or the mobile phase, was performed. The surfactants used were anionic; sodium dodecyl sulphate, and cationic; cetrimide. The studied analytes include phenyl-ephrine hydrochloride (PHR), cetirizine dihydrochloride (CTZ), and mebeverine hydrochloride (MBV). Successful separation of the enantiomers was attained, giving promising results that may cause a revolution in chiral separation, predicting the possibility of simply prepared aqueous micellar mobile phases of carrying chiral selector ability. The second motive of this work is studying the compatibility of hybrid micelle liquid mobile phases with chiral columns separating CTZ, using cellulose 1 chiral column as a model example. This study may be an environmentally safe substitute for the normal phase mode of elution that is usually applied for chiral separation consuming large amounts of hazardous organic solvents.

Automated summary

The study introduces two new concepts related to chiral separation: successful chiral separation of enantiomeric drugs using micelle-based liquid chromatography without chiral selectors, and the compatibility of hybrid micelle liquid mobile phases with chiral columns. These concepts could potentially revolutionize chiral separation methods and offer an environmentally safe alternative to traditional elution methods.