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Humoral Immunity against SARS-CoV-2 and the Impact on COVID-19 Pathogenesis

期刊

MOLECULES AND CELLS
卷 44, 期 6, 页码 392-400

出版社

KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
DOI: 10.14348/molcells.2021.0075

关键词

COVID-19; humoral immunity; neutralizing antibody; SARS-CoV-2; SARS-CoV-2 variants

资金

  1. National Research Foundation of Korea [NRF-2021R1C1C1004546, NRF-2021M3A9H3015689]
  2. National Research Foundation of Korea [2021M3A9H3015689] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

向作者/读者索取更多资源

This article introduces key findings on humoral immune responses in COVID-19, including the immune dynamics of antibody responses and correlations with disease severity, neutralizing antibodies and their cross-reactivity, the duration of antibody and memory B-cell responses, aberrant autoreactive antibodies in COVID-19 patients, and the efficacy of currently available therapeutic antibodies and vaccines against circulating SARS-CoV-2 variants, while also highlighting gaps in current knowledge.
It has been more than a year since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first emerged. Many studies have provided insights into the various aspects of the immune response in coronavirus disease 2019 (COVID-19). Especially for antibody treatment and vaccine development, humoral immunity to SARS-CoV- 2 has been studied extensively, though there is still much that is unknown and controversial. Here, we introduce key discoveries on the humoral immune responses in COVID-19, including the immune dynamics of antibody responses and correlations with disease severity, neutralizing antibodies and their cross-reactivity, how long the antibody and memory B-cell responses last, aberrant autoreactive antibodies generated in COVID-19 patients, and the efficacy of currently available therapeutic antibodies and vaccines against circulating SARS-CoV-2 variants, and highlight gaps in the current knowledge.

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