期刊
CONTEMPORARY CLINICAL TRIALS
卷 45, 期 -, 页码 55-60出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cct.2015.07.006
关键词
Stepped wedge design; Cluster randomized trial; Implementation research
资金
- National Institute of Allergy and Infectious Diseases [AI29168]
The use of stepped wedge designs in cluster-randomized trials and implementation studies has increased rapidly in recent years but there remains considerable debate regarding the merits of the design. We discuss three key issues in the design and analysis of stepped wedge trials - time-on-treatment effects, treatment effect heterogeneity and cohort studies. (C) 2015 Elsevier Inc. All rights reserved.
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