期刊
FEBS LETTERS
卷 591, 期 14, 页码 2035-2047出版社
WILEY
DOI: 10.1002/1873-3468.12656
关键词
Dmc1; DNA repair; genome stability; homologous recombination; Rad51; Swi5-Sfr1
资金
- Japan Society for the Promotion of Science [15H059749]
- Grants-in-Aid for Scientific Research [17K15061, 16H06160, 16H01404] Funding Source: KAKEN
Homologous recombination (HR) is the process whereby two DNA molecules that share high sequence similarity are able to recombine to generate hybrid DNA molecules. Throughout evolution, the ability of HR to identify highly similar DNA sequences has been adopted for numerous biological phenomena including DNA repair, meiosis, telomere maintenance, ribosomal DNA amplification and immunological diversity. Although Rad51 and Dmc1 are the key proteins that promote HR in mitotic and meiotic cells, respectively, accessory proteins that allow Rad51 and Dmc1 to effectively fulfil their functions have been identified in all examined model systems. In this Review, we discuss the roles of the highly conserved Swi5-Sfr1 accessory complex in yeast, mice and humans, and explore similarities and differences between these species.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据