期刊
FEBS LETTERS
卷 592, 期 2, 页码 209-218出版社
WILEY
DOI: 10.1002/1873-3468.12948
关键词
cardiolipin; CRLS1; mitochondrial morphology; phosphatidylglycerol
资金
- Japan Society for the Promotion of Science (JSPS) [17H03676]
- JST CREST [JPMJCR12M1]
- Grants-in-Aid for Scientific Research [15H05705, 17H03676] Funding Source: KAKEN
Mitochondrial tubular structures are maintained by a balance between membrane fusion and fission that is regulated by various factors, including Drp1 and mitofusin/fzo-1. Here we report the role of cardiolipin (CL) synthase in the regulation of mitochondrial morphology. Knockdown of CL synthase induced mitochondrial elongation in nematode and human cells. Knockdown of both nematode cardiolipin synthase and drp-1 or fzo-1 suggested that knocking down CL synthase decreases mitochondrial division. Mass spectrometric analysis of human CL synthase-knocked down cells revealed a decreased amount of CL and an accumulation of phosphatidylglycerol, a CL precursor. Knockdown of other genes involved in CL synthesis did not influence mitochondrial morphology. Thus, mitochondrial elongation may result from the accumulation of phosphatidylglycerol rather than decreased CL.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据