期刊
FEBS LETTERS
卷 591, 期 6, 页码 889-902出版社
WILEY
DOI: 10.1002/1873-3468.12604
关键词
peroxiredoxin1; vascular development; zebrafish
资金
- Ministry of Science and Technology, Taiwan, R.O.C. [MOST103-2311-B-110-004, MOST104-2311-B-110-001-MY3]
- NSYSU-KMU Joint Research Project [NSYSUKMU105-P017]
- Ministry of Science and Technology in Taiwan [MOST-103-2321-B-001-050, MOST-104-2321-B-001-045]
Genetic signaling and redox homeostasis are required for proper growth of blood vessels. Here, we report a novel function of peroxiredoxin1 (Prdx1) in vascular development in zebrafish. Knockdown of prdx1 impairs the growth of intersegmental vessel and caudal vein plexus (CVP), and reduces the expression of vascular markers, thus suggesting a role for prdx1 in vasculature and indicating that the antioxidant function of prdx1 is important. We found that H2O2-treated embryos also have CVP defects and observed synergistic effects when prdx1 knockdown was combined with H2O2 treatment. Moreover, N-acetyl-cysteine treatment rescues the vascular defects in prdx1 morphants. These results suggest that oxidative stress disturbs vascularization. Furthermore, we show that the regulation of prdx1 is mediated by Notch and BMP signals.
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