期刊
FEBS LETTERS
卷 591, 期 10, 页码 1333-1348出版社
WILEY
DOI: 10.1002/1873-3468.12661
关键词
linear elastic model; peripheral membrane proteins; wavy lipid membrane
资金
- Department of Biotechnology, Ministry of Science and Technology, Government of India [BT/PR8025/BRB/10/1203/2013]
We carry out a linear elastic analysis to study wavy structure generation on lipid membrane by peripheral membrane proteins. We model the lipid membrane as linearly elastic and anisotropic material. The hydrophobic insertion by proteins into the lipid membrane has been idealized as penetration of rigid rod-like inclusions into the membrane and the electrostatic interaction between protein and membrane has been modeled by a distributed surface traction acting on the membrane surface. With the proposed model we study curvature generation by several binding domains of peripheral membrane proteins containing BAR domains and amphipathic alpha-helices. It is observed that electrostatic interaction is essential for curvature generation by the BAR domains.
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