期刊
FEBS LETTERS
卷 592, 期 8, 页码 1330-1345出版社
WILEY
DOI: 10.1002/1873-3468.12944
关键词
membrane fluidity; phospholipid molecular species; phospholipid properties
资金
- Division of Chemical Sciences in the Netherlands
- Netherlands Organization for Scientific Research (NWO)
In most eukaryotes, including Saccharomyces cerevisiae, glycerophospholipids are the main membrane lipid constituents. Besides serving as general membrane 'building blocks', glycerophospholipids play an important role in determining the physical properties of the membrane, which are crucial for proper membrane function. To ensure optimal physical properties, membrane glycerophospholipid composition and synthesis are tightly regulated. This review will summarize our current knowledge of factors and processes determining the membrane glycerophospholipid composition of the reference eukaryote S. cerevisiae at the level of molecular species. Extrapolating from relevant model membrane data, we also discuss how modulation of the molecular species composition can regulate membrane physical properties.
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