期刊
FEBS JOURNAL
卷 284, 期 18, 页码 2932-2946出版社
WILEY
DOI: 10.1111/febs.14078
关键词
ADP-ribosylation; cellular pathways; metabolism of ADP-ribosylation; poly(ADP-ribose) polymerase; post-translational modification
资金
- Wellcome Trust [101794]
- Cancer Research UK [C35050/A22284]
- European Research Council [281739]
- Croatian Science Foundation [IP-2016-06-4242]
- Cancer Research UK [22284] Funding Source: researchfish
Rapid response to environmental changes is achieved by uni- and multicellular organisms through a series of molecular events, often involving modification of macromolecules, including proteins, nucleic acids and lipids. Amongst these, ADP-ribosylation is of emerging interest because of its ability to modify different macromolecules in the cells, and its association with many key biological processes, such as DNA-damage repair, DNA replication, transcription, cell division, signal transduction, stress and infection responses, microbial pathogenicity and aging. In this review, we provide an update on novel pathways and mechanisms regulated by ADP-ribosylation in organisms coming from all kingdoms of life.
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