相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Amyloid precursor protein and endosomal-lysosomal dysfunction in Alzheimer's disease: inseparable partners in a multifactorial disease
Ralph A. Nixon
FASEB JOURNAL (2017)
IRE1 signaling exacerbates Alzheimer's disease pathogenesis
Claudia Duran-Aniotz et al.
ACTA NEUROPATHOLOGICA (2017)
When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157
Diego Rojas-Rivera et al.
CELL DEATH AND DIFFERENTIATION (2017)
Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice
Mark Halliday et al.
BRAIN (2017)
Targeting ABL-IRE1α Signaling Spares ER- Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes
Shuhei Morita et al.
CELL METABOLISM (2017)
The unfolded protein response: mechanisms and therapy of neurodegeneration
Heather L. Smith et al.
BRAIN (2016)
Gene therapy to target ER stress in brain diseases
Vicente Valenzuela et al.
BRAIN RESEARCH (2016)
Protein misfolding in the endoplasmic reticulum as a conduit to human disease
Miao Wang et al.
NATURE (2016)
Regulation of Memory Formation by the Transcription Factor XBP1
Gabriela Martinez et al.
CELL REPORTS (2016)
Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch
Ciara M. Gallagher et al.
ELIFE (2016)
Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation
Lars Plate et al.
ELIFE (2016)
A small molecule targeting protein translation does not rescue spatial learning and memory deficits in the hAPP-J20 mouse model of Alzheimer's disease
Erik C. B. Johnson et al.
PEERJ (2016)
Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury
Maritza Onate et al.
SCIENTIFIC REPORTS (2016)
Aβ42 oligomers modulate β-secretase through an XBP-1s-dependent pathway involving HRD1
Yannis Gerakis et al.
SCIENTIFIC REPORTS (2016)
Endoplasmic Reticulum Stress and the Hallmarks of Cancer
Hery Urra et al.
TRENDS IN CANCER (2016)
The unfolded protein response in neurodegenerative diseases: a neuropathological perspective
Wiep Scheper et al.
ACTA NEUROPATHOLOGICA (2015)
PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia
Helois Radford et al.
ACTA NEUROPATHOLOGICA (2015)
Lipid-dependent regulation of the unfolded protein response
Romain Volmer et al.
CURRENT OPINION IN CELL BIOLOGY (2015)
Proteostasis control by the unfolded protein response
Claudio Hetz et al.
NATURE CELL BIOLOGY (2015)
Proteostasis and aging
Susmita Kaushik et al.
NATURE MEDICINE (2015)
Amyloid-β pathology is attenuated by tauroursodeoxycholic acid treatment in APP/PS1 mice after disease onset
Pedro A. Dionisio et al.
NEUROBIOLOGY OF AGING (2015)
Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit
Indrajit Das et al.
SCIENCE (2015)
Mutations in a translation initiation factor identify the target of a memory-enhancing compound
Yusuke Sekine et al.
SCIENCE (2015)
Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity
M. Halliday et al.
CELL DEATH & DISEASE (2015)
Cellular Mechanisms of Endoplasmic Reticulum Stress Signaling in Health and Disease. 1. An overview
Estefanie Dufey et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2014)
Pathological roles of ceramide and its metabolites in metabolic syndrome and Alzheimer's disease
Kohei Yuyama et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2014)
Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal across Brain Regions
Jimena Baleriola et al.
CELL (2014)
The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells
Jennifer Jurkin et al.
EMBO JOURNAL (2014)
Unfolded protein response signaling by transcription factor XBP-1 regulates ADAM10 and is affected in Alzheimer's disease
Sven Reinhardt et al.
FASEB JOURNAL (2014)
Serum Calreticulin Is a Negative Biomarker in Patients with Alzheimer's Disease
Qiao Lin et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)
Druggable sensors of the unfolded protein response
Dustin J. Maly et al.
NATURE CHEMICAL BIOLOGY (2014)
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases
Claudio Hetz et al.
NATURE REVIEWS NEUROSCIENCE (2014)
PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease
Latha Devi et al.
NEUROBIOLOGY OF AGING (2014)
Gene Therapy for the Nervous System: Challenges and New Strategies
Casey A. Maguire et al.
NEUROTHERAPEUTICS (2014)
Effects of Oxidative Stress on the Solubility of HRD1, a Ubiquitin Ligase Implicated in Alzheimer's Disease
Ryo Saito et al.
PLOS ONE (2014)
Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1
Pamela Valdes et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis
Min Lu et al.
SCIENCE (2014)
Memory loss in Alzheimer's disease: are the alterations in the UPR network involved in the cognitive impairment?
Claudia Duran-Aniotz et al.
FRONTIERS IN AGING NEUROSCIENCE (2014)
Roles of eIF2α kinases in the pathogenesis of Alzheimer's disease
Masuo Ohno
FRONTIERS IN MOLECULAR NEUROSCIENCE (2014)
Physiological roles of regulated Ire1 dependent decay
Dina S. Coelho et al.
FRONTIERS IN GENETICS (2014)
Ca2+-dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid -treated astrocytes and in a model of Alzheimer's disease
Elena Alberdi et al.
AGING CELL (2013)
When ER stress reaches a dead end
Hery Urra et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)
Modeling Alzheimer's Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness
Takayuki Kondo et al.
CELL STEM CELL (2013)
Polymorphism - 116C/G of Human X-box-Binding Protein 1 Promoter is Associated with Risk of Alzheimer's Disease
Sheng-Yuan Liu et al.
CNS NEUROSCIENCE & THERAPEUTICS (2013)
Exploiting the selectivity of protein phosphatase 1 for pharmacological intervention
Pavel Tsaytler et al.
FEBS JOURNAL (2013)
Role of the Unfolded Protein Response in Organ Physiology: Lessons from Mouse Models
Victor Hugo Cornejo et al.
IUBMB LIFE (2013)
The ire-1 ER stress-response pathway is required for normal secretory-protein metabolism in C. elegans
Modi Safra et al.
JOURNAL OF CELL SCIENCE (2013)
Tau Accumulation Activates the Unfolded Protein Response by Impairing Endoplasmic Reticulum-Associated Degradation
Jose F. Abisambra et al.
JOURNAL OF NEUROSCIENCE (2013)
Trehalose rescues Alzheimer's disease phenotypes in APP/PS1 transgenic mice
Jing Du et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2013)
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death
Jaeseok Han et al.
NATURE CELL BIOLOGY (2013)
Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits
Tao Ma et al.
NATURE NEUROSCIENCE (2013)
Targeting the unfolded protein response in disease
Claudio Hetz et al.
NATURE REVIEWS DRUG DISCOVERY (2013)
Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains
Romain Volmer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-ß oligomers
Rui O. Costa et al.
AGING CELL (2012)
MV-mediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation in a mouse model of Huntington's disease
Amparo Zuleta et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma
Naoya Mimura et al.
BLOOD (2012)
Silencing of Lipid Metabolism Genes through IRE1α-Mediated mRNA Decay Lowers Plasma Lipids in Mice
Jae-Seon So et al.
CELL METABOLISM (2012)
Hrd1 Facilitates Tau Degradation and Promotes Neuron Survival
Y. X. Shen et al.
CURRENT MOLECULAR MEDICINE (2012)
Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy
Rene L. Vidal et al.
HUMAN MOLECULAR GENETICS (2012)
Proteolytic processing of Alzheimer's ss-amyloid precursor protein
Han Zhang et al.
JOURNAL OF NEUROCHEMISTRY (2012)
The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies
Diana A. T. Nijholt et al.
JOURNAL OF PATHOLOGY (2012)
Endoplasmic Reticulum Enrollment in Alzheimer's Disease
Ricardo J. S. Viana et al.
MOLECULAR NEUROBIOLOGY (2012)
Sustained translational repression by eIF2α-P mediates prion neurodegeneration
Julie A. Moreno et al.
NATURE (2012)
Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors
Likun Wang et al.
NATURE CHEMICAL BIOLOGY (2012)
The unfolded protein response: controlling cell fate decisions under ER stress and beyond
Claudio Hetz
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
Amyloid β-induced ER stress is enhanced under mitochondrial dysfunction conditions
Rui O. Costa et al.
NEUROBIOLOGY OF AGING (2012)
Mechanism-Based Screen for G1/S Checkpoint Activators Identifies a Selective Activator of EIF2AK3/PERK Signalling
Simon R. Stockwell et al.
PLOS ONE (2012)
InterfERing with endoplasmic reticulum stress
Honorata Kraskiewicz et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2012)
Activation of the unfolded protein response enhances motor recovery after spinal cord injury
V. Valenzuela et al.
CELL DEATH & DISEASE (2012)
The Ubiquitin-Proteasome System and the Autophagic-Lysosomal System in Alzheimer Disease
Yasuo Ihara et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Consequences of Inhibiting Amyloid Precursor Protein Processing Enzymes on Synaptic Function and Plasticity
Hui Wang et al.
NEURAL PLASTICITY (2012)
Kalirin-7 is necessary for normal NMDA receptor-dependent synaptic plasticity
Fouad Lemtiri-Chlieh et al.
BMC NEUROSCIENCE (2011)
The ER stress factor XBP1s prevents amyloid-β neurotoxicity
Sergio Casas-Tinto et al.
HUMAN MOLECULAR GENETICS (2011)
Hippocampal phenotypes in kalirin-deficient mice
Zhong Xie et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2011)
Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis
Pavel Tsaytler et al.
SCIENCE (2011)
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
Peter Walter et al.
SCIENCE (2011)
Alzheimer's Disease: β-Amyloid Plaque Formation in Human Brain
Philip Seeman et al.
SYNAPSE (2011)
Chemical and Biological Approaches for Adapting Proteostasis to Ameliorate Protein Misfolding and Aggregation Diseases-Progress and Prognosis
Susan L. Lindquist et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)
Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis
Norman J. Haughey et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2010)
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
Goekhan S. Hotamisligil
CELL (2010)
Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice
Jin Hwan Lee et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2010)
Amyloid-beta as a Modulator of Synaptic Plasticity
Mordhwaj S. Parihar et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
Translational Control Mechanisms in Long-lasting Synaptic Plasticity and Memory
Christos Gkogkas et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
The Role of the BDNF Val66Met Polymorphism for the Synchronization of Error-Specific Neural Networks
Christian Beste et al.
JOURNAL OF NEUROSCIENCE (2010)
eIF2α Phosphorylation-Dependent Translation in CA1 Pyramidal Cells Impairs Hippocampal Memory Consolidation without Affecting General Translation
Zhihong Jiang et al.
JOURNAL OF NEUROSCIENCE (2010)
Loss of HRD1-Mediated Protein Degradation Causes Amyloid Precursor Protein Accumulation and Amyloid-β Generation
Masayuki Kaneko et al.
JOURNAL OF NEUROSCIENCE (2010)
Correlation Between Decrease in Protein Levels of Ubiquitin Ligase HRD1 and Amyloid-β Production
Ryo Saito et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2010)
Translational Regulation of Gene Expression during Conditions of Cell Stress
Keith A. Spriggs et al.
MOLECULAR CELL (2010)
Direct Current Stimulation Promotes BDNF-Dependent Synaptic Plasticity: Potential Implications for Motor Learning
Brita Fritsch et al.
NEURON (2010)
Activation of PERK Signaling Attenuates Aβ-Mediated ER Stress
Do Yeon Lee et al.
PLOS ONE (2010)
The Unfolded Protein Response Protects from Tau Neurotoxicity In Vivo
Carin A. Loewen et al.
PLOS ONE (2010)
The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus
Jeroen J. M. Hoozemans et al.
AMERICAN JOURNAL OF PATHOLOGY (2009)
Salubrinal, an inhibitor of protein synthesis, promotes deep slow wave sleep
Melvi M. Methippara et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2009)
Ubiquitination and cysteine nitrosylation during aging and Alzheimer's disease
Irene M. Riederer et al.
BRAIN RESEARCH BULLETIN (2009)
IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates
Dan Han et al.
CELL (2009)
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
Claudio Hetz et al.
GENES & DEVELOPMENT (2009)
A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory
Ursula Haditsch et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2009)
Fine-Tuning of the Unfolded Protein Response: Assembling the IRE1α Interactome
Claudio Hetz et al.
MOLECULAR CELL (2009)
The role of tau in neurodegeneration
Tania F. Gendron et al.
MOLECULAR NEURODEGENERATION (2009)
Translational Control of Long-Lasting Synaptic Plasticity and Memory
Mauro Costa-Mattioli et al.
NEURON (2009)
Phenylbutyrate Ameliorates Cognitive Deficit and Reduces Tau Pathology in an Alzheimer's Disease Mouse Model
Ana Ricobaraza et al.
NEUROPSYCHOPHARMACOLOGY (2009)
Kalirin-7 Is Required for Synaptic Structure and Function
Xin-Ming Ma et al.
JOURNAL OF NEUROSCIENCE (2008)
Aβ inhibits the proteasome and enhances amyloid and tau accumulation
Bertrand P. Tseng et al.
NEUROBIOLOGY OF AGING (2008)
Linking calcium to Aβ and Alzheimer's disease
Kim N. Green et al.
NEURON (2008)
Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis
Tracy O'Connor et al.
NEURON (2008)
Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis
Claudio Hetz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Adapting proteostasis for disease intervention
William E. Balch et al.
SCIENCE (2008)
The endoplasmic reticulum stress response in immunity and autoimmunity
Derrick J. Todd et al.
NATURE REVIEWS IMMUNOLOGY (2008)
The role of brain-derived neurotrophic factor (BDNF)- induced XBP1 splicing during brain development
Akiko Hayashi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
IRE1 signaling affects cell fate during the unfolded protein response
Jonathan H. Lin et al.
SCIENCE (2007)
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6α and XBP1
Keisuke Yamamoto et al.
DEVELOPMENTAL CELL (2007)
XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks
Diego Acosta-Alvear et al.
MOLECULAR CELL (2007)
Signal integration in the endoplasmic reticulum unfolded protein response
David Ron et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
eIF2α phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory
Mauro Costa-Mattioli et al.
CELL (2007)
A beta Oligomers - a decade of discovery
Dominic M. Walsh et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response
Julie Hollien et al.
SCIENCE (2006)
Intrinsic capacities of molecular sensors of the unfolded protein response to sense alternate forms of endoplasmic reticulum stress
Jenny B. DuRose et al.
MOLECULAR BIOLOGY OF THE CELL (2006)
S-Nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration
Takashi Uehara et al.
NATURE (2006)
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1α-mediated NF-κB activation and down-regulation of TRAF2 expression
P Hu et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
The unfolded protein response is activated in Alzheimer's disease
JJM Hoozemans et al.
ACTA NEUROPATHOLOGICA (2005)
A selective inhibitor-of eIF2α dephosphorylation protects cells from ER stress
M Boyce et al.
SCIENCE (2005)
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells
KM Vattem et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Association of the XBP1-116C/G polymorphism with schizophrenia in the Japanese population
C Kakiuchi et al.
PSYCHIATRY AND CLINICAL NEUROSCIENCES (2004)
Protein quality control in Alzheimer's disease by the ubiquitin proteasome system
FMS de Vrij et al.
PROGRESS IN NEUROBIOLOGY (2004)
Essential role of E2-25K/Hip-2 in mediating amyloid-β neurotoxicity
S Song et al.
MOLECULAR CELL (2003)
Inducible enhancement of memory storage and synaptic plasticity in transgenic mice expressing an inhibitor of ATF4 (CREB-2) and C/EBP proteins
A Chen et al.
NEURON (2003)
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
HP Harding et al.
MOLECULAR CELL (2003)
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
MF Egan et al.
CELL (2003)
XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
AH Lee et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Unfolding the role of protein misfolding in neurodegenerative diseases
C Soto
NATURE REVIEWS NEUROSCIENCE (2003)
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
M Calfon et al.
NATURE (2002)
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
H Yoshida et al.
CELL (2001)
The β-secretase, BACE -: A prime drug target for Alzheimer's disease
R Vassar
JOURNAL OF MOLECULAR NEUROSCIENCE (2001)
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2α
I Novoa et al.
JOURNAL OF CELL BIOLOGY (2001)
Protein oxidation in the brain in Alzheimer's disease
MY Aksenov et al.
NEUROSCIENCE (2001)
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
J Ye et al.
MOLECULAR CELL (2000)
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
A Bertolotti et al.
NATURE CELL BIOLOGY (2000)
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
F Urano et al.
SCIENCE (2000)
ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response
H Yoshida et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)