期刊
FEBS JOURNAL
卷 284, 期 9, 页码 1267-1278出版社
WILEY
DOI: 10.1111/febs.13987
关键词
autophagosome; endosome; lysosome; membrane trafficking; PI3P
资金
- INSERM
- CNRS
- Universite Paris-Descartes-Sorbonne Paris Cite
- INCa
- ANR
- 'Association pour la Recherche contre le Cancer' (ARC)
Phosphatidylinositol-3-phosphate (PI3P) is a key player in membrane dynamics and trafficking regulation. Most PI3P is associated with endosomal membranes and with the autophagosome preassembly machinery, presumably at the endoplasmic reticulum. The enzyme responsible for most PI3P synthesis, VPS34 and proteins such as Beclin1 and ATG14L that regulate PI3P levels are positive modulators of autophagy initiation. It had been assumed that a local PI3P pool was present at autophagosomes and preautophagosomal structures, such as the omegasome and the phagophore. This was recently confirmed by the demonstration that PI3P-binding proteins participate in the complex sequence of signalling that results in autophagosome assembly and activity. Here we summarize the historical discoveries of PI3P lipid kinase involvement in autophagy, and we discuss the proposed role of PI3P during autophagy, notably during the autophagosome biogenesis sequence.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据