相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Mitochondrial Dynamics: Coupling Mitochondrial Fitness with Healthy Aging
David Sebastian et al.
TRENDS IN MOLECULAR MEDICINE (2017)
DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis
Mateus Milani et al.
CELL DEATH & DISEASE (2017)
BCL-2 family proteins as regulators of mitochondria metabolism
Atan Gross
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2016)
The dynamic subcellular localization of ERK: mechanisms of translocation and role in various organelles
Ehud Wainstein et al.
CURRENT OPINION IN CELL BIOLOGY (2016)
The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis
Arnim Weber et al.
EMBO REPORTS (2016)
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
Andras Kotschy et al.
NATURE (2016)
A draft map of the mouse pluripotent stem cell spatial proteome
Andy Christoforou et al.
NATURE COMMUNICATIONS (2016)
Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming
Javier Prieto et al.
NATURE COMMUNICATIONS (2016)
Mitophagy is primarily due to alternative autophagy and requires the MAPK1 and MAPK14 signaling pathways
Yuko Hirota et al.
AUTOPHAGY (2015)
CDK5 phosphorylates DRP1 and drives mitochondrial defects in NMDA-induced neuronal death
Arezu Jahani-Asl et al.
HUMAN MOLECULAR GENETICS (2015)
Mitochondrial Division Is Requisite to RAS-Induced Transformation and Targeted by Oncogenic MAPK Pathway Inhibitors
Madhavika N. Serasinghe et al.
MOLECULAR CELL (2015)
Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth
Jennifer A. Kashatus et al.
MOLECULAR CELL (2015)
Extracellular Regulated Kinase Phosphorylates Mitofusin 1 to Control Mitochondrial Morphology and Apoptosis
Aswin Pyakurel et al.
MOLECULAR CELL (2015)
Small molecule Mcl-1 inhibitors for the treatment of cancer
Johannes Belmar et al.
PHARMACOLOGY & THERAPEUTICS (2015)
Regulation of mitochondrial nutrient and energy metabolism by BCL-2 family proteins
Alfredo Gimenez-Cassina et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2015)
Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)
J. D. Leverson et al.
CELL DEATH & DISEASE (2015)
Oncogenic KRAS sensitizes premalignant, but not malignant cells, to Noxa-dependent apoptosis through the activation of the MEK/ERK pathway
Annalisa Conti et al.
ONCOTARGET (2015)
Noxa upregulation by oncogenic activation of MEK/ERK through CREB promotes autophagy in human melanoma cells
Yi Lun Liu et al.
Oncotarget (2015)
MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road
Christopher J. Caunt et al.
NATURE REVIEWS CANCER (2015)
The increase in BIK expression following ERK1/2 pathway inhibition is a consequence of G1 cell-cycle arrest and not a direct effect on BIK protein stability
Matthew J. Sale et al.
BIOCHEMICAL JOURNAL (2014)
Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer's disease cybrid cell
Xueqi Gan et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)
MCL-1 but not BCL-XL is critical for the development and sustained expansion of thymic lymphoma in p53-deficient mice
Stephanie Grabow et al.
BLOOD (2014)
A Novel Small-Molecule Inhibitor of Mcl-1 Blocks Pancreatic Cancer Growth In Vitro and In Vivo
Fardokht Abulwerdi et al.
MOLECULAR CANCER THERAPEUTICS (2014)
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
Peter E. Czabotar et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
CDK5-dependent inhibitory phosphorylation of Drp1 during neuronal maturation
Bongki Cho et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2014)
Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond
Matthew Holderfield et al.
NATURE REVIEWS CANCER (2014)
The BH3 mimetic ABT-263 synergizes with the MEK1/2 inhibitor selumetinib/AZD6244 to promote BIM-dependent tumour cell death and inhibit acquired resistance
Matthew J. Sale et al.
BIOCHEMICAL JOURNAL (2013)
Requirement for antiapoptotic MCL-1 in the survival of BCR-ABL B-lineage acute lymphoblastic leukemia
Brian Koss et al.
BLOOD (2013)
Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models
Ryan B. Corcoran et al.
CANCER CELL (2013)
The BH3-mimetic ABT-737 sensitizes human melanoma cells to apoptosis induced by selective BRAF inhibitors but does not reverse acquired resistance
David Wroblewski et al.
CARCINOGENESIS (2013)
Dual-specificity MAP kinase phosphatases (MKPs): Shaping the outcome of MAP kinase signalling
Christopher J. Caunt et al.
FEBS JOURNAL (2013)
Cyclin-dependent kinases regulate splice-specific targeting of dynamin-related protein 1 to microtubules
Stefan Strack et al.
JOURNAL OF CELL BIOLOGY (2013)
Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission
Oliver C. Loson et al.
MOLECULAR BIOLOGY OF THE CELL (2013)
Bcl-2/Bcl-xL Inhibition Increases the Efficacy of MEK Inhibition Alone and in Combination with PI3 Kinase Inhibition in Lung and Pancreatic Tumor Models
Nguyen Tan et al.
MOLECULAR CANCER THERAPEUTICS (2013)
Oncogenic RAS simultaneously protects against anti-EGFR antibody-dependent cellular cytotoxicity and EGFR signaling blockade
S. Kasper et al.
ONCOGENE (2013)
Bioenergetic role of mitochondrial fusion and fission
Benedikt Westermann
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2012)
Src tyrosine kinase inhibits apoptosis through the Erk1/2-dependent degradation of the death accelerator Bik
J. Lopez et al.
CELL DEATH AND DIFFERENTIATION (2012)
Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia
Stefan P. Glaser et al.
GENES & DEVELOPMENT (2012)
Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease
Andrew W. Roberts et al.
JOURNAL OF CLINICAL ONCOLOGY (2012)
ERK2 phosphorylation of serine 77 regulates Bmf pro-apoptotic activity
Y. Shao et al.
CELL DEATH & DISEASE (2012)
High-Glucose Stimulation Increases Reactive Oxygen Species Production Through the Calcium and Mitogen-Activated Protein Kinase-Mediated Activation of Mitochondrial Fission
Tianzheng Yu et al.
ANTIOXIDANTS & REDOX SIGNALING (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Somatic Oxidative Bioenergetics Transitions into Pluripotency-Dependent Glycolysis to Facilitate Nuclear Reprogramming
Clifford D. L. Folmes et al.
CELL METABOLISM (2011)
Mitochondrial Fusion: Bax to the Fussure
Seamus J. Martin
DEVELOPMENTAL CELL (2011)
BIMEL, an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation
Ceri M. Wiggins et al.
JOURNAL OF CELL SCIENCE (2011)
Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival
Mohamed Elgendy et al.
MOLECULAR CELL (2011)
Epidermal growth factor regulates Mcl-1 expression through the MAPK-Elk-1 signalling pathway contributing to cell survival in breast cancer
E. P. Booy et al.
ONCOGENE (2011)
Amplification of the Driving Oncogene, KRAS or BRAF, Underpins Acquired Resistance to MEK1/2 Inhibitors in Colorectal Cancer Cells
Annette S. Little et al.
SCIENCE SIGNALING (2011)
BIM Expression in Treatment-Naive Cancers Predicts Responsiveness to Kinase Inhibitors
Anthony C. Faber et al.
CANCER DISCOVERY (2011)
Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1
Derek Yecies et al.
BLOOD (2010)
Akt3-Mediated Resistance to Apoptosis in B-RAF-Targeted Melanoma Cells
Yongping Shao et al.
CANCER RESEARCH (2010)
Membrane Remodeling Induced by the Dynamin-Related Protein Drp1 Stimulates Bax Oligomerization
Sylvie Montessuit et al.
CELL (2010)
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells
Hidenori Otera et al.
JOURNAL OF CELL BIOLOGY (2010)
The BCL-2 Family Reunion
Jerry E. Chipuk et al.
MOLECULAR CELL (2010)
Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity
Wyndham H. Wilson et al.
LANCET ONCOLOGY (2010)
The landscape of somatic copy-number alteration across human cancers
Rameen Beroukhim et al.
NATURE (2010)
Mitochondria and cell death: outer membrane permeabilization and beyond
Stephen W. G. Tait et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
An ERK-dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs
C. Sheridan et al.
ONCOGENE (2010)
The Mammalian MAPK/ERK Pathway Exhibits Properties of a Negative Feedback Amplifier
Oliver E. Sturm et al.
SCIENCE SIGNALING (2010)
The ERK signaling cascade-Views from different subcellular compartments
Zhong Yao et al.
BIOFACTORS (2009)
Mitogen-Activated Protein Kinase Inhibition Induces Translocation of Bmf to Promote Apoptosis in Melanoma
Matthew W. VanBrocklin et al.
CANCER RESEARCH (2009)
Tumour cell survival signalling by the ERK1/2 pathway
K. Balmanno et al.
CELL DEATH AND DIFFERENTIATION (2009)
Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERKI/2 signalling and/or strong P13K signalling in colorectal cancer cell lines
Kathryn Balmanno et al.
INTERNATIONAL JOURNAL OF CANCER (2009)
Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands
Erinna F. Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
βTrCP- and Rsk1/2-Mediated Degradation of BimEL Inhibits Apoptosis
Elinor Dehan et al.
MOLECULAR CELL (2009)
Cell fate decisions are specified by the dynamic ERK interactome
Alex von Kriegsheim et al.
NATURE CELL BIOLOGY (2009)
A New Paradigm for MAPK: Structural Interactions of hERK1 with Mitochondria in HeLa Cells
Soledad Galli et al.
PLOS ONE (2009)
Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress
Ruben K. Dagda et al.
AUTOPHAGY (2008)
C-RAF activation promotes BAD poly-ubiquitylation and turn-over by the proteasome
Jochen Fueller et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Mitochondrial fusion, fission and autophagy as a quality control axis: The bioenergetic view
Gilad Twig et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2008)
Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax)
Marina Konopleva et al.
CANCER RESEARCH (2008)
ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor
Christin Tse et al.
CANCER RESEARCH (2008)
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
Gilad Twig et al.
EMBO JOURNAL (2008)
Extracellular signal-regulated kinase activation by Neisseria gonorrhoeae downregulates epithelial cell proapoptotic proteins bad and bim
Heather L. Howie et al.
INFECTION AND IMMUNITY (2008)
Oncogenic B-RafV600E inhibits apoptosis and promotes ERK-dependent inactivation of Bad and Bim
Clare Sheridan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic
Mark S. Cragg et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway
W. Zhang et al.
LEUKEMIA (2008)
The ground state of embryonic stem cell self-renewal
Qi-Long Ying et al.
NATURE (2008)
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
Jer-Yen Yang et al.
NATURE CELL BIOLOGY (2008)
Colorectal cancer cells with the BRAF(V600E) mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM
J. A. Wickenden et al.
ONCOGENE (2008)
A Mitochondrial Kinase Complex Is Essential to Mediate an ERK1/2-Dependent Phosphorylation of a Key Regulatory Protein in Steroid Biosynthesis
Cecilia Poderoso et al.
PLOS ONE (2008)
Drp1 phosphorylation and mitochondrial regulation
Chuang-Rung Chang et al.
EMBO REPORTS (2007)
Functions and dysfunctions of mitochondrial dynamics
Scott A. Detmer et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Apoptosis induction in human melanoma cells by inhibition of MEK is caspase-independent and mediated by the Bcl-2 family members PUMA, Bim, and Mcl-1
Yu Fang Wang et al.
CLINICAL CANCER RESEARCH (2007)
Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins
Craig Brooks et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL
Katherine E. Ewings et al.
EMBO JOURNAL (2007)
The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition
S. Meloche et al.
ONCOGENE (2007)
Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission
Naoko Taguchi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Structural insights into the degradation of Mcl-1 induced by BH3 domains
Peter E. Czabotar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Patterns of somatic mutation in human cancer genomes
Christopher Greenman et al.
NATURE (2007)
A high glycolytic flux supports the proliferative potential of murine embryonic stem cells
Hiroshi Kondoh et al.
ANTIOXIDANTS & REDOX SIGNALING (2007)
Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737
Victoria Del Gaizo Moore et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets
M. G. Hinds et al.
CELL DEATH AND DIFFERENTIATION (2007)
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
Mark F. van Delft et al.
CANCER CELL (2006)
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
Marina Konopleva et al.
CANCER CELL (2006)
Role of Bax and Bak in mitochondrial morphogenesis
Mariusz Karbowski et al.
NATURE (2006)
FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal
Han You et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2006)
Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1
U Maurer et al.
MOLECULAR CELL (2006)
The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions
S Yoon et al.
GROWTH FACTORS (2006)
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
T Oltersdorf et al.
NATURE (2005)
BH3 domains of BH3-only proteins differentially regulate bax-mediated mitochondrial membrane permeabilization both directly and indirectly
T Kuwana et al.
MOLECULAR CELL (2005)
The role of Bcl-2 family members in tumorigenesis
V Kirkin et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2004)
The importance of intrinsic disorder for protein phosphorylation
LM Iakoucheva et al.
NUCLEIC ACIDS RESEARCH (2004)
An unstructured initiation site is required for efficient proteasome-mediated degradation
S Prakash et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)
Ternary complex factor-serum response factor complex-regulated gene activity is required for cellular proliferation and inhibition of apoptotic cell death
ER Vickers et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol
AM Domina et al.
ONCOGENE (2004)
The phosphorylation status and anti-apoptotic activity of Bcl-2 are regulated by ERK and protein phosphatase 2A on the mitochondria
Y Tamura et al.
FEBS LETTERS (2004)
Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim
R Ley et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis
K Lei et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins
F Legros et al.
MOLECULAR BIOLOGY OF THE CELL (2002)
Activation of JNK1, RSK2, and MSK1 is involved in serine 112 phosphorylation of bad by ultraviolet B radiation
QB She et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Bmf: A proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis
H Puthalakath et al.
SCIENCE (2001)
Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells
E Smirnova et al.
MOLECULAR BIOLOGY OF THE CELL (2001)
Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
PF Dijkers et al.
CURRENT BIOLOGY (2000)
Rsk1 mediates a MEK-MAP kinase cell survival signal
A Shimamura et al.
CURRENT BIOLOGY (2000)
分享论文
