期刊
SCIENCE ADVANCES
卷 7, 期 22, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abe7738
关键词
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资金
- National Natural Science Foundation of China [61875015, 51872031, 82001982]
- Beijing Natural Science Foundation [JQ20038, 7204333]
- China Postdoctoral Science Foundation [2020M680302, 2019M660410]
- Fundamental Research Funds for the Central Universities
- National Youth Talent Support Program
This study developed a force mapping method based on a light nano-antenna array with the use of piezo-phototronic effect, achieving high-resolution dynamic mapping of cell-generated force. The methodology can be applied for fundamental study of cardiomyocyte behavior and provide valuable information for heart-related research.
Dynamic mapping of the cell-generated force of cardiomyocytes will help provide an intrinsic understanding of the heart. However, a real-time, dynamic, and high-resolution mapping of the force distribution across a single living cell remains a challenge. Here, we established a force mapping method based on a light nano-antenna array with the use of piezo-phototronic effect. A spatial resolution of 800 nm and a temporal resolution of 333 ms have been demonstrated for force mapping. The dynamic mapping of cell force of live cardiomyocytes was directly derived by locating the antennas' positions and quantifying the light intensities of the piezo-phototronic light nano-antenna array. This study presents a rapid and ultrahigh-resolution methodology for the fundamental study of cardiomyocyte behavior at the cell or subcellular level. It can provide valuable information about disease detection, drug screening, and tissue engineering for heart-related studies.
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