期刊
CONTEMPORARY CLINICAL TRIALS
卷 45, 期 -, 页码 93-102出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cct.2015.06.007
关键词
Adaptive design; Adaptive randomization; Bayesian inference; Early stopping; Hybrid resampling; Multi-arm bandits
资金
- NSF [DMS-1106535]
- NIH [1 P30 CA124435-01]
- National Center for Research Resources, National Institutes of Health [UL1 RR025744]
- Direct For Mathematical & Physical Scien
- Division Of Mathematical Sciences [1407828] Funding Source: National Science Foundation
The past decade witnessed major developments in innovative designs of confirmatory clinical trials, and adaptive designs represent the most active area of these developments. We give an overview of the developments and associated statistical methods in several classes of adaptive designs of confirmatory trials. We also discuss their statistical difficulties and implementation challenges, and show how these problems are connected to other branches of mainstream Statistics, which we then apply to resolve the difficulties and bypass the bottlenecks in the development of adaptive designs for the next decade. (C) 2015 Elsevier Inc. All rights reserved.
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