期刊
FASEB JOURNAL
卷 31, 期 11, 页码 4959-4970出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.201700093R
关键词
ASZ1; germline gene regulation; mitochondria
资金
- Ministry of Science and Technology of China [2016YFA0100300, 2014CB964800]
- National Natural Science Foundation of China [31471347, 31271589, 16JC1404200, 11DZ2260300]
- Science and Technology Commission of Shanghai Municipality, China [1ZICHL006058]
- Intramural Research Program of the U.S. National Institutes of Health, National Heart Lung Blood Institute
Spermatogenesis is a highly coordinated process that requires tightly regulated gene expression programmed by transcription factors and epigenetic modifiers. In this study, we found that nuclear respiratory factor (NRF)-1, a key transcription factor for mitochondrial biogenesis, cooperated with DNA methylation to directly regulate the expression of multiple germ cell-specific genes, including Asz1. In addition, conditional ablation of NRF1 in gonocytes dramatically down-regulated these germline genes, blocked germ cell proliferation, and subsequently ledtomale infertility in mice. Our data highlight a precise crosstalk between transcriptional regulation by NRF1 and epigenetic modulation during germ cell development and unequivocally demonstrate a novel role of NRF1 in spermatogenesis.-Wang, J., Tang, C., Wang, Q., Su, J., Ni, T., Yang, W., Wang, Y., Chen, W., Liu, X., Wang, S., Zhang, J., Song, H., Zhu, J., Wang, Y. NRF1 coordinates with DNA methylation to regulate spermatogenesis.
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