期刊
FASEB JOURNAL
卷 31, 期 1, 页码 29-34出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.201600781R
关键词
gender; methods; sex influences; sex differences
资金
- NCATS NIH HHS [UL1 TR001422] Funding Source: Medline
- NHLBI NIH HHS [R01 HL119380, R01 HL131182] Funding Source: Medline
- NIA NIH HHS [P50 AG044170] Funding Source: Medline
- NICHD NIH HHS [R01 HD076125] Funding Source: Medline
In June 2015, the National Institutes of Health (NIH) released a Guide notice (NOT-OD-15-102) that highlighted the expectation of the NIH that the possible role of sex as a biologic variable be factored into research design, analyses, and reporting of vertebrate animal and human studies. Anticipating these guidelines, the NIH Office of Research on Women's Health, in October 2014, convened key stakeholders to discuss methods and techniques for integrating sex as a biologic variable in preclinical research. The workshop focused on practical methods, experimental design, and approaches to statistical analyses in the use of both male and female animals, cells, and tissues in preclinical research. Workshop participants also considered gender as a modifier of biology. This article builds on the workshop and is meant as a guide to preclinical investigators as they consider methods and techniques for inclusion of both sexes in preclinical research and is not intended to prescribe exhaustive/specific approaches for compliance with the new NIH policy.-Miller, L.R., Marks, C., Becker, J. B., Hurn, P. D., Chen, W.-J., Woodruff, T., McCarthy, M. M., Sohrabji, F., Schiebinger, L., Wetherington, C. L., Makris, S., Arnold, A. P., Einstein, G., Miller, V. M., Sandberg, K., Maier, S., Cornelison, T. L., Clayton, J. A. Considering sex as a biological variable in preclinical research.
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