期刊
FASEB JOURNAL
卷 31, 期 11, 页码 4665-4681出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.201700336R
关键词
choroidal neovascularization; corneal angiogenesis; macular degeneration; retinal vasculature; retinopathy
资金
- U.S. National Institutes of Health (NIH), National Eye Institute [R01-EY024963]
- Boston Children's Hospital Ophthalmology Foundation
- Massachusetts Lions Eye Research Fund, Inc.
- BrightFocus Foundation
- Knights Templar Eye Foundation Pediatric Ophthalmology Career-Starter Research Grants
- Boston Children's Hospital Faculty Career Development Grant OFD/BTREC/CTREC
Pathological angiogenesis in the eye is an important feature in the pathophysiology of many vision-threatening diseases, including retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration, as well as corneal diseases with abnormal angiogenesis. Development of reproducible and reliable animal models of ocular angiogenesis has advanced our understanding of both the normal development and the pathobiology of ocular neovascularization. These models have also proven to be valuable experimental tools with which to easily evaluate potential antiangiogenic therapies beyond eye research. This review summarizes the current available animal models of ocular angiogenesis. Models of retinal and choroidal angiogenesis, including oxygen-induced retinopathy, laser-induced choroidal neovascularization, and transgenic mouse models with deficient or spontaneous retinal/choroidal neovascularization, as well as models with induced corneal angiogenesis, are widely used to investigate the molecular and cellular basis of angiogenic mechanisms. Theoretical concepts and experimental protocols of these models are outlined, as well as their advantages and potential limitations, which may help researchers choose the most suitable models for their investigative work.
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