期刊
INORGANIC CHEMISTRY FRONTIERS
卷 8, 期 5, 页码 1189-1196出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0qi01308k
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资金
- Regione Autonoma della Sardegna [RASSR79857]
- Universita di Sassari (fondo di Ateneo per la ricerca 2020)
The ESI-MS and EPR results obtained from studying systems containing vanadium-protein adducts were explained by integrating the spectrometric and spectroscopic responses with molecular modelling simulations. The covalent and non-covalent binding interactions in representative systems with lysozyme and cytochrome c were fully characterized. This approach should be considered for all metal-protein systems to achieve full characterization of binding types.
The ESI-MS and EPR results obtained during the study of systems containing vanadium-protein adducts have been explained integrating the spectrometric and spectroscopic responses with molecular modelling simulations. The representative systems formed by the potential antibacterial drug [(VO)-O-IV (nalidixato)(2)(H2O)l with lysozyme and cytochrome c were fully characterized, interpreting the ESI-MS and EPR signals as the result of covalent and non-covalent binding. This behaviour should be considered for all metal-protein systems, and instrumental techniques - if necessary should be coupled with modelling to achieve full characterization of the types of binding.
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