期刊
CHEMICAL COMMUNICATIONS
卷 57, 期 50, 页码 6161-6164出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc01623g
关键词
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资金
- National Science Foundation [CHE-1750295]
- American Heart Association [20PRE35120390]
- NSF [CHE-1531632]
- Cornell Institute of Biotechnology Imaging Facility - NIH [S10RR025502]
- NIH [R01-GM129345]
The investigation found that Co3+ complexes can inhibit MCU activity with nanomolar potency, and they operate through interactions with the DIME motif of the MCU pore.
We report our investigation into the MCU-inhibitory activity of Co3+ complexes in comparison to Ru265. These compounds reversibly inhibit the MCU with nanomolar potency. Mutagenesis studies and molecular docking simulations suggest that the complexes operate through interactions with the DIME motif of the MCU pore.
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