4.6 Article

A cyclodextrin-phenylboronic acid cross-linked hydrogel with drug hosting, self-healing and pH-sensitive properties for sustained drug release

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NEW JOURNAL OF CHEMISTRY
卷 45, 期 24, 页码 10711-10717

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ROYAL SOC CHEMISTRY
DOI: 10.1039/d1nj01228b

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  1. Natural Science Basic Research Plan in Shaanxi Province of China [2020JM-420]

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A hydrogel with self-healing, drug hosting, and pH-sensitive properties was prepared by loading salicylic acid into beta-CD and using cyclodextrin-phenylboronic acid as a cross-linker. The hydrogel exhibited excellent mechanical properties and biocompatibility, enabling sustained drug release.
The rapid drug release and poor self-healing properties of drug-loaded hydrogels largely limit their practical application. Herein, we present a simple method to prepare hydrogels with self-healing, drug hosting and pH-sensitive properties for sustained drug release. First, salicylic acid was loaded into beta-CD through host-guest interactions. The hydrogel was then constructed through the polymerization of acrylamide using cyclodextrin-phenylboronic acid as a reversible, pH-sensitive cross-linker. The obtained hydrogel exhibited outstanding stretchability (1150%), good tensile strength (42 kPa), excellent self-healing properties (90%) and high biocompatibility. Besides, the introduction of the cyclodextrin-phenylboronic acid cross-linker endowed the hydrogel with pH-sensitive and sustained drug release properties. These functions enable cyclodextrin-phenylboronic acid cross-linked hydrogels to be drug hosting, self-healing and pH-sensitive flexible materials for sustained drug release, making them a powerful platform for various biomedical applications.

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