Metabolically engineered bacteria as light-controlled living therapeutics for anti-angiogenesis tumor therapy

A living therapeutic system based on attenuated Salmonella was developed via metabolic engineering using an aggregation-induced emission (AIE) photosensitizer MA. The engineered bacteria could localize in the tumor tissues and continue to colonize and express exogenous genes. Under light irradiation, the encoded VEGFR2 gene was released and expressed in tumor tissues, which can suppress angiogenesis induced by a T cell-mediated autoimmune response and inhibit tumor growth.

Automated summary

A living therapeutic system based on attenuated Salmonella was developed through metabolic engineering with an AIE photosensitizer MA. These engineered bacteria could specifically target tumor tissues, colonize, and express exogenous genes, which leads to the suppression of angiogenesis and tumor growth.