期刊
出版社
WILEY
DOI: 10.1002/dad2.12189
关键词
Alzheimer' s disease; autonomic dysfunction; dementia with Lewy bodies; Lewy body disease; mixed dementia
资金
- Ralph Fisher and Alzheimer Society of BC Professorship in dementia research
Patients with both ADNC and LBP have a higher prevalence of DLB symptoms compared to those with pure ADNC, and autonomic dysfunction can serve as a marker for the presence of LBP.
Introduction Patients with Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) frequently demonstrate coexistent AD neuropathological change (ADNC) and Lewy body pathology (LBP) at autopsy. We investigated the effects of ADNC and LBP on the clinical presentation of these patients. Methods We retrospectively compared clinical and pathological features of patients with different severity of ADNC and LBP. We also compared the burden of medullary LBP between patients with and without autonomic dysfunction. Results Compared to pure ADNC, patients with AD/LBP have higher prevalence of DLB symptoms. Autonomic dysfunction strongly predicted the presence of LBP in patients with clinically diagnosed AD, but was not associated with increased LBP burden in the medulla. Severity of ADNC, but not LBP, was associated with cerebral atrophy. Discussion Clinical presentation of patients with AD/LBP differs from patients with pure ADNC or LBP. Autonomic dysfunction is a useful marker of otherwise unsuspected LBP.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据