Cobalt- and iron-catalyzed regiodivergent alkene hydrosilylations

A complementary set of base metal catalysts has been developed for regiodivergent alkene hydrosilylations: iron complexes of amine-iminopyridine ligands are selective for Markovnikov hydrosilylations (branched/linear up to >99 : 1), while the cobalt complexes bearing the same type of ligands provide excellent levels of anti-Markovnikov selectivity (linear/branched up to >99 : 1). Both systems exhibit high efficiency and wide functional group tolerance.

Automated summary

A complementary set of base metal catalysts has been developed for regiodivergent alkene hydrosilylations: iron complexes exhibit high selectivity for Markovnikov hydrosilylations, while cobalt complexes provide excellent anti-Markovnikov selectivity. Both systems are highly efficient and tolerant to a wide range of functional groups.