Characteristic clinical features associated with aggressive posterior retinopathy of prematurity

Purpose To identify the risk factors for, and clinical features and treatment outcomes of aggressive posterior retinopathy of prematurity (APROP) in Korean infants. Methods Among 770 premature infants who underwent screening, 105 infants (198 eyes, 13.63%) received treatment for ROP. A total of 24 infants (48 eyes, 3.12%) developed APROP while 81 infants (150 eyes, 10.52%) developed non-APROP treatment-requiring type. The medical records of ROP-treated infants were reviewed retrospectively. The associated systemic and maternal risk factors were analyzed and anatomical outcomes were compared according to the severity of ROP and treatment modalities. Results The mean gestational age and birth weight at birth in the APROP group were significantly lower than those in the nonAPROP group (P = 0.019, P < 0.001, respectively). Infants who were born small for their GA developed APROP more frequently than non-APROP patients (P < 0.001). Chorioamnionitis-positive infants also showed higher incidence rate of APROP (APROP vs non-APROP; P < 0.001 and zone I APROP vs posterior zone II APROP; P = 0.036, respectively). Infants with APROP required heavier laser treatment with a higher retreatment rate compared to infants with non-APROP. Favorable anatomical outcomes were achieved in 95.3% from treatmentrequiring non-APROP group, 85.7% from zone I APROP and 84.6% from posterior zone II APROP group. Conclusion Intrauterine growth restriction and chorioamnionitis were associated with development of APROP. These findings suggest that perinatal maternal environment inhibiting normal retinal vascular growth in utero may contribute to increasing the risk of APROP in premature infants.