期刊
ORGANIC CHEMISTRY FRONTIERS
卷 8, 期 10, 页码 2287-2314出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1qo00101a
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Asymmetric organocatalysis is a versatile method for enantioselective alpha-functionalization of aldehydes, with a focus on diverse catalysts and heteroatomic modifications. Research has also delved into understanding the catalytic cycle and reaction mechanisms, leading to the development of novel catalysts with superior chemoselectivity. Three general synthetic applications, including Horner-Wadsworth-Emmons, aldol, and organometallic addition reactions, are examined, along with examples of functional group chemistry and their downstream reactivities.
Asymmetric organocatalysis has proven to be one of the most versatile methods for the enantioselective alpha-functionalisation of aldehydes. Initially pioneered by the report of an L-proline catalysed intermolecular aldol reaction, the field has seen a diversification in the range of catalysts as well as heteroatomic modifications at the alpha-stereocenter. From the original reports of these synthetic procedures, additional focus has been on understanding the catalytic cycle and mechanism of reaction. This has led primarily to the development of novel catalysts with superior chemoselectivity and better understanding of catalyst deactivation pathways. Additionally, the demand and synthetic scope for chiral alpha-heteroatom substituted aldehydes is examined in the three general synthetic applications: the Horner-Wadsworth-Emmons, aldol and organometallic addition reactions. In each of these example applications common examples of functional group chemistry and their downstream reactivities are reviewed. Interesting total synthesis applications are also highlighted.
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