Photoinitiated stereoselective direct C(sp2)-H perfluoroalkylation and difluoroacetylation of enamides

A photoinitiated perfluoroalkylative coupling of enamides with perfluoroalkyl iodides and a visible-light-induced difluoroacetylation of enamides with ethyl bromodifluoroacetate have been developed, respectively. These transformations allow the efficacious and straightforward incorporation of biologically and physiologically privileged fluoro-containing moieties into synthetically eminent enamide scaffolds with excellent regio- and stereoselectivities under mild and environmentally friendly conditions.

Automated summary

These methods utilize photocatalysis to efficiently incorporate fluorine-containing moieties into synthetically superior enamide scaffolds under mild and environmentally friendly conditions, with high regio- and stereoselectivities.