4.6 Article

Preparation of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones via base-assisted cyclization of 3-cyanoketones

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RSC ADVANCES
卷 11, 期 27, 页码 16236-16245

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ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ra02279b

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  1. Russian Science Foundation [19-73-00091]
  2. Russian Science Foundation [19-73-00091] Funding Source: Russian Science Foundation

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This new preparative method allows for the rapid assembly of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones from readily available synthetic precursors, which could not be prepared using previously known protocols.
A convenient preparative method is developed allowing for expeditious assembly of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones from routinely available inexpensive synthetic precursors. These compounds could not be prepared via the previously known protocols, as 2-aminofuran derivatives were produced instead.

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