Integrating Engineering, Automation, and Intelligence to Catalyze the Biomedical Translation of Organoids

Organoid technology has developed at an impressive speed during the past decade. Still, organoids are not widely used in practical applications as expected. It is believed that this translation can be greatly accelerated with the integration of engineering and artificial intelligence into current research practices. It is proposed that this approach is the missing link to realize key milestones in organoid technology, namely, high-throughput, homogeneous, and standardized production, automated manipulation, and intelligent monitoring, evaluation, and control via integrated on-chip instrumentation and artificial intelligence. It is suggested that organoids-on-a-chip are the ideal platform to achieve these feats. Once these techniques are established and adopted by the scientific community, the rapid translation of organoids may be seen from laboratories to the clinics and pharmaceutical industry.

Automated summary

Organoid technology has advanced rapidly, but its practical applications are still limited. Integrating engineering and artificial intelligence into research practices may accelerate the translation of organoids, with organoids-on-a-chip proposed as an ideal platform for achieving high-throughput, automated manipulation, and intelligent monitoring and control. Once established and adopted by the scientific community, rapid translation of organoids from laboratories to clinics and pharmaceutical industry may be realized.